营养屋实验室 - 营养屋
  • 产品展示
  • 基础亚博体育官方平台
  • 美容瘦身
  • 改善睡眠
  • 生长发育
  • 胃肠道
  • 养护关节
  • 男性健康
  • 名贵滋补
  • 视力保健
  • 心脑血管健康
  • 亚博体育官方平台屋创始人陈耀明博士,学贯中西,领衔组建了亚博体育官方平台屋实验室。实验室长期致力于前沿医药和亚博体育官方平台学的研究,发表了大量研究论文,拥有多项专利。

    陈博士带领一行科学家,秉承“亚博体育官方平台促进健康”理念,运用现代医学研发技术,将创新的研究成果、优质的特色资源经过严谨的配方论证和功效试验筛选,研发优选出功效卓著的复合配方亚博体育官方平台保健品。


    1. 2'-Deoxyisoinosine and 8-Aza-7-deaza-2'-deoxyisoinosine Form Base Pairs with 2'-   Deoxycytidine and 2'Deoxyisocytidine, Y. Chen,G.Becher, F. Seela, Nucleosides &   Nucleotides, submitted.

    2. The Sugar Conformation of 8-Azaz-1,3-dideaza-2'-deoxyadenosine in Solid State and Solution, Y. Chen, F. Seela, in Preparation.

    3. 7-Deazapurine Oligodeoxyribonucleotides: The Effects of 7-Deaza-8-methylguanine on DNA-Structure and Stability, F. Seela, Y. Chen, C.Mittelbach, Helv. Chim. Acta. 1998, 81, 570.

    4. Synthesis of 2',3'-Didehydro-2',3'-Dideoxyisoinosine and Oxidation of Fluorescent 2-Hydroxypurine Nucleosides by Xanthine Oxidase, F.Seela, Y. Chen, M. Sauer,Nucleosides & Nucleotides 1998, 17, 39.

    5. Regioselectivity of the Mannich Reaction on Pyrrolo[2,3-d]pyrimidine Nucleosides Related to 7-Deaza -2'-deoxyadenosines or 7-Deaza-2'-deoxyguanosines, F. Seela, Y. Chen, M. Zulauf, Synthesis 1997, 1067.

    6. Methylated DNA: The Influence of 7-Deaza-7-methylguanine on the Structure and Stabilityof Oligonucleotides, F. Seela, Y. Chen, Helv. Chim. Acta 1997, 80, 1073.

    7. Steric and stereoelectronic Effect of 7-deazapurine Bases on the Surgar Confomation of Nucleosides, H. Rosemeyer, N. Ramzaeva,M. Zulauf, H. Thomas, Y. Chen, C. Mittelbach, F. Seela, Nucleosides & Nucleotides 1997, 16, 1447.

    8. 7-Nitro-7-deaza-2'-deoxyadenosine and 8-Methyl-7-deaza-2'-deoxyguanosine:Pyrrolo[2,3-d]pyrimidine Nucleosides with Different Sugar Conformations, F. Seela, H. Rosemeyer, M. Zulauf, Y. Chen, G. Kastner, H. Reute,Liebigs. Ann. Chem. 1997, 2525.

    9. Oligonucleotides Containing 7- or 8-Methyl-7-deazaguanine: Steric Requirements of Major Groove Substituents on the DNA Structure,F. Seela, Y. Chen, Chem. Commun. 1996, 2263.

    10. Synthesis and Application of Novel Nucleoside Phosphonates and Phosphoramidites Modified at the Base Moiety, F. Seela, Y. Chen,A. Melenewski,H. Rosemeyer, C. Wei, Acta Biochimica Polonica. 1996, 43, 45.

    11. Oligonucleotides Containing 7-Deazaguanine: the Role of 7- and 8-Methyl Groups During the B-Z Transition of DAN, F. Seela, Y. Chen,Collect. Czech. Chem. 1996, 61, 112.

    12. Oligonucleotides Containing Fluorescent 2'-Deoxyisoinosine: Solid-Phase Synthesis and Duplex Stability, F. Seela, Y. Chen, NucleicAcids Res. 1995, 23, 2499.

    13. Oligonucleotide Duplex Stability Controlled by the 7-Substituents of 7-Deazaguanine Bases, F. Seela, N. Ramzaeva, Y. Chen, Bioorg.Med. Chem. Lett. 1995, 5, 3049.

    14. 2'-Deoxyisoinosine: Synthesis of a Highly Fluorescent Nucleoside and Its Incorporation into Oligonucleotides, F. Seela, Y. Chen,Nucleosides & Nucleotides 1995, 14, 863.

    15. Synthesis of 2'-Deoxyisoinosine and Related 2'-Deoxyribonucleosides”, F. Seela, Y. Chen, U. Bindig, Z. Kazimierczuk, Helv. Chim.Acta 1994, 77, 194.

    16. Synthesis of N-(4-Carbethoxy-4-Substituted Butyl)-N-Substituted Glycines, and the Evaluation of their Angiotensin Converting EnzymeInhibitors (ACEI) Activities, Y. Chen, C.-Y. Cai, K.-S. Gong, Acta Pharmaceutica Sinica 1989, 24, 887.

    1. Purine analog nucleoside and nucleotide compounds.Seela, Frank; Bourgeouis,Werner; Gumbiowski, Rainer; Roling, Angelika; Rosemeyer, Helmut; Mertens, Alfred; Zilch, Harald;Konig, Bernhard; Koch, Edith. (Boehringer Mannheim GmbH, Mannheim, Germany), US-Patent 5,446,139 1995.

    2. Desazapurin-Nucleosid-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung bei der Nucleinsure-Sequenzierungsowie als antivirale MittelSeela, F.; Muth, H.-P.; Kaiser, K.; Bourgeois, W.; Mühlegger, K.; von der Eltz, H.; Batz, H.-G. (Boehringer Mannheim GmbH,Mannheim, Germany), EU-Patent 0 286 028 B1 1995.

    3. Nucleosid-Derivate und deren Verwendung als ArzneimittelSeela, F.; Bourgeois, W.; Gumbiowski, R.; Roeling, A.; Rosemeyer, H.; Mertens, A.; Zilch, H.; Konig, B.; Koch, E. (BoehringerMannheim GmbH, Mannheim, Germany), EU-Patent 0 666 269 A2 1995.

    4. 7-Deaza-2’-deoxyguanosine nucleotides and nucleic acids analogs thereofSeela, F. (Boehringer Mannheim GmbH, Mannheim, Germany), US-Patent 5,480,980 1996.

    5. Modified oligonucleotides, their preparation and their use.Seela, Frank; Thomas, Horst. (Hoechst Aktiengesellschaft, Germany), US-Patent 5,844,106 1998.

    6. Nucleotide monomers containing 8-azapurin bases or a derivative thereof, their preparation and their use in makingmodified oligonucleotidesSeela, F, Lampe S. (Hoechst AG, Frankfurt, Germany), US-Patent 5,789,562 1998.

    7. Synthesis of 7-deaza-2’deoxyguanosine nucleotidesSeela, F. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 5,990,303 1999.

    8. Modified oligonucleotides, their preparation and their useSeela, F.; Lampe, S. (Hoechst AG, Frankfurt, Germany), US-Patent 6,066,720 2000.

    9. Modified oligonucleotides, their preparation and their useSeela, Frank; Thomas, Horst (Aventis Pharma Deutschland GmbH, Frankfurt am Main, Germany), US-Patent 6,150,510 2000.

    10. Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containingthem and the use thereof for nucleic acid sequencing and as antiviral agents.Seela, Frank; Muth, Heinz-Peter; Kaiser, Klaus; Bourgeois, Werner; Mühlegger, Klaus, von der Eltz, Herbert, Batz, Hans-Georg.(Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 6,211,158 B1 2001.

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